2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101873
    Atorvastatin lactone
    Atorvastatin lactone is a myotoxic reagent and a metabolite of Atorvastatin acid, an HMG-CoA reductase inhibitor. Atorvastatin lactone exhibits myotoxicity.
    Atorvastatin lactone
  • HY-136239
    Beclomethasone 17-propionate
    		99.52%
    Beclomethasone 17-propionate (Beclomethasone-17-monopropionate), an active metabolite of Beclomethasone dipropionate (HY-13571), is a glucocorticoid receptor (GR) agonist. Beclomethasone 17-propionate exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in chronic obstructive pulmonary disease (COPD) lung macrophages.
    Beclomethasone 17-propionate
  • HY-G0018
    Norgestimate metabolite Norelgestromin
    		99.89%
    Norgestimate metabolite Norelgestromin (17-Deacetyl norgestimate) is a metabolite of Norgestimate (HY-W013172). Norgestimate metabolite Norelgestromin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Norgestimate metabolite Norelgestromin
  • HY-N7715
    Ferulic acid acyl-β-D-glucoside
    		99.33%
    Ferulic acid acyl-β-D-glucoside (Ferulic acid glucoside) is a metabolite of Ferulic Acid (HY-N0060). Ferulic acid acyl-β-D-glucoside can be isolated from flaxseed extract. Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50 values of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.
    Ferulic acid acyl-β-D-glucoside
  • HY-A0111
    Cefetamet
    		99.06%
    Cefetamet (Ro 15-8074) is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil (HY-B1894A). Cefetamet binds to bacterial penicillin-binding protein (PBP) (IC50 for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet kills and lyses Treponema pallidum. Cefetamet can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis.
    Cefetamet
  • HY-14925
    Lapaquistat
    		99.81%
    Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of Lapaquistat acetate (HY-16274). Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy.
    Lapaquistat
  • HY-W053507
    m-Tolylacetic acid
    		99.93%
    m-Tolylacetic acid (3-Methylbenzeneacetic acid) is a hydroaromatic dicarboxylic acids excreted in the urine as metabolite of tolueneacetic acid. m-Tolylacetic acid can be used for drug intermediate for synthesising more complex molecules.
    m-Tolylacetic acid
  • HY-130189
    S-Phenylmercapturic acid
    		99.38%
    S-Phenylmercapturic acid, a metabolite of benzene, can be used as a biomarker, identified by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassay.
    S-Phenylmercapturic acid
  • HY-W086896
    α-Demethylnaproxen
    		99.76%
    α-Demethylnaproxen is the major metabolite of Nabumetone (HY-B0559), Nabumetone is an orally active COX-2 inhibitor with anti-inflammatory activity.
    α-Demethylnaproxen
  • HY-W009538
    5'-Deoxy-5-fluorocytidine
    		99.91%
    5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer.
    5'-Deoxy-5-fluorocytidine
  • HY-B0652
    Etonogestrel
    		99.91%
    Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs. Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs).
    Etonogestrel
  • HY-138253S
    2′,2′-Difluorodeoxyuridine-13C,15N2
    		99.50%
    2′,2′-Difluorodeoxyuridine-13C,15N2 (dFdU-13C,15N2) is a 13C- and 15N-labeled compound. 2’,2’-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2’,2’-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro. 2’,2’-Difluorodeoxyuridine arrests cell cycle at the early S phase and induces apoptosis in cancer cells.
    2′,2′-Difluorodeoxyuridine-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-133668
    Monoethyl phthalate
    		98.58%
    Monoethyl phthalate is an orally active PDX-1 activator and the major hydrolytic metabolite of Diethyl phthalate (HY-Y0284) in vivo, with reproductive toxicity. Monoethyl phthalate targets aromatase (aromatase/CYP19A1) and PPAR to induce cell proliferation. The plasma protein binding rate of Monoethyl phthalate in rats and humans is lower than that of Diethyl phthalate. It exhibits significant enterohepatic circulation in rats and mainly accumulates in liver tissues. Monoethyl phthalate shows no estrogenic activity in estrogen-dependent human breast cancer cells. Monoethyl phthalate can be used in studies of reproductive toxicity and related environmental endocrine disruption mechanisms.
    Monoethyl phthalate
  • HY-137967
    Genistein 7-β-D-Glucuronide
    		98.76%
    Genistein 7-β-D-Glucuronide (Genistein 7-O-glucuronide) is the primary phase II metabolite of Genistein (HY-14596) in human and rat hepatocytes. Genistein 7-β-D-Glucuronide undergoes distinct deconjugation in different functional assays. Genistein 7-β-D-Glucuronide is produced via hepatic microsomal glucuronidation and shows a mild age-related increase in intrinsic clearance in male F344 rats. Genistein 7-β-D-Glucuronide can be used for research on metabolism.
    Genistein 7-β-D-Glucuronide
  • HY-113269
    alpha-CEHC
    		99.30%
    alpha-CEHC is a water-soluble metabolite of alpha-tocopherol (α-TOH) with potential antioxidant activity. alpha-CEHC slightly inhibits macrophage-induced low-density lipoprotein (LDL) oxidation, and its inhibitory potency is concentration-dependent.
    alpha-CEHC
  • HY-10002R
    Calcitriol (Standard)
    Calcitriol (Standard) is the analytical standard of Calcitriol. This product is intended for research and analytical applications. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
    Calcitriol (Standard)
  • HY-173258
    5-Carboxy-2′-deoxycytidine
    		98.10%
    5-Carboxy-2′-deoxycytidine is a metabolite of Trifluridine (HY-A0061).
    5-Carboxy-2′-deoxycytidine
  • HY-W585952
    Salicylic acid 2-O-β-D-glucoside
    Salicylic acid 2-O-β-D-glucoside (SA-2-O-β-D-glucoside) is the glucose-conjugated product of Salicylic Acid (HY-B0167) in plants. Salicylic acid 2-O-β-D-glucoside belongs to an inactive storage form. Salicylic acid 2-O-β-D-glucoside can be used in studies of plant pathogen infection.
    Salicylic acid 2-O-β-D-glucoside
  • HY-101955A
    (2R,6R)-Hydroxynorketamine hydrochloride
    		99.91%
    (2R,6R)-Hydroxynorketamine ((2R,6R)-HNK) hydrochloride is an active ketamine metabolite with no NMDAR binding activity. (2R,6R)-Hydroxynorketamine hydrochloride rescues impaired dorsal hippocampal long-term potentiation and restores robust long-term potentiation in the hippocampal SC-CA1 pathway. (2R,6R)-Hydroxynorketamine hydrochloride can be used for research on depression.
    (2R,6R)-Hydroxynorketamine hydrochloride
  • HY-N8210
    Homoeriodictyol
    		99.86%
    Homoeriodictyol is an orally active, bitter-tasting flavanone that can penetrate the blood-brain barrier. Homoeriodictyol enhances synaptic-related protein expression through NCOA4-mediated ferritin autophagy. Homoeriodictyol improves memory impairment in mice by inhibiting the NLRP3 inflammasome. Homoeriodictyol protects human endothelial cells from oxidative damage by activating Nrf2 and inhibiting mitochondrial dysfunction. Homoeriodictyol enhances ROS activity and induces apoptosis, exhibiting anticancer effects. Homoeriodictyol inhibits the survival and migration of androgen-resistant prostate cancer cells in vitro. Homoeriodictyol exerts antinociceptive activity in mice in vivo.
    Homoeriodictyol
Cat. No. Product Name / Synonyms Application Reactivity